Protein Variants | Comment | Organism |
---|---|---|
additional information | BACE1-driven reporter protein expression, transfection of rat cortical cultures | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P56817 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell line | glioblastoma-astrocytoma cell line U373, nuclear extracts used for promoter-protein binding studies | Homo sapiens | - |
HeLa cell | nuclear extracts used for promoter-protein binding studies, hypoxic cells included | Homo sapiens | - |
lymphoma cell line | U937, nuclear extracts used for promoter-protein binding studies | Homo sapiens | - |
neuroblastoma cell line | NB, nuclear extracts used for promoter-protein binding studies | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
characterization of structure and regulatory region of the beta-secretase BACE1 promoter, more repetitive elements in BACE1 than in BACE2 identified, regulatory domains of BACE1 promoter shown to be different from those of BACE2, DNA-protein interaction studies performed, BACE1-driven reporter protein expression shown to be higher than those of BACE2, operation of BACE1 through a single transcriptional control site suggested, differences to BACE2 summarized, genomic mapping of BACE1 and BACE2 on chromosome and of functional domains performed | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | structure and regulatory elements of beta-secretase BACE1 promoter analyzed, comparative model of transcriptional regulation between BACE1 and BACE2 presented | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |